Increasing population pressure and decreasing cultivable land brought the agricultural sector at an alarming situation of food production particularly in the developing countries. To feed the burgeoning population, the agriculture sector needs to become more productive and diversified while facing the adversity of climate change and limitations of natural resources. During 1960-70, the improved irrigation facilities, the use of fertilizers and pesticides in the cultivation of high yielding varieties of cereals successfully led to the Green revolution in India. In the present scenario, the low irrigation and fertilizer use efficiencies, poor pesticide application and delivery are amongst the important issues in developing countries that need to be addressed for getting higher productivity. Also, fertilizer and pesticide usage also had severe associated environmental consequences like eutrophication, resistance and resurgence in pest, toxicity to non-target organisms, residues in food and feed, accumulation in the environment, etc. In such conditions, organic farming, a traditional practice coupled with the exploration of bio-nanoparticles to achieve a sustainable production system seems to be a better option. This review focuses on current research developments in the areas of bio-nano-enabled crop nutrition, protection, post-harvest management, and the possibility of bio-nanomaterials and organic farming confluence to revolutionize the agricultural sector by ensuring sustainable food security for coming generations.