Vaccine effectiveness against SARS-CoV-2 transmission to household contacts during dominance of Delta variant (B.1.617.2), the Netherlands, August to September 2021

Brechje de Gier; Stijn Andeweg; Jantien A Backer; RIVM COVID-19 surveillance and epidemiology team; Susan Jm Hahné; Susan van den Hof; Hester E de Melker; Mirjam J Knol; RIVM COVID-19 surveillance and epidemiology team (in addition to the named authors)

doi:10.2807/1560-7917.ES.2021.26.44.2100977

Vaccine effectiveness against SARS-CoV-2 transmission to household contacts during dominance of Delta variant (B.1.617.2), the Netherlands, August to September 2021

Euro Surveill. 2021 Nov;26(44):2100977. doi: 10.2807/1560-7917.ES.2021.26.44.2100977.

Authors

Brechje de Gier¹, Stijn Andeweg¹, Jantien A Backer¹; RIVM COVID-19 surveillance and epidemiology team²; Susan Jm Hahné¹, Susan van den Hof¹, Hester E de Melker¹, Mirjam J Knol¹; RIVM COVID-19 surveillance and epidemiology team (in addition to the named authors)

Collaborators

Agnetha Hofhuis, Anne Teirlinck, Alies van Lier, Bronke Boudewijns, Miek de Dreu, Anne-Wil Valk, Femke Jongenotter, Carolien Verstraten, Gert Broekhaar, Guido Willekens, Irene Veldhuijzen, Jan Polman, Jan van de Kassteele, Jeroen Alblas, Janneke van Heereveld, Janneke Heijne, Kirsten Bulsink, Lieke Wielders, Liselotte van Asten, Liz Jenniskens, Loes Soetens, Maarten Mulder, Maarten Schipper, Marit de Lange, Naomi Smorenburg, Nienke Neppelenbroek, Patrick van den Berg, Priscila de Oliveira Bressane Lima, Rolina van Gaalen, Sara Wijburg, Shahabeh Abbas Zadeh, Siméon de Bruijn, Senna van Iersel, Sjoerd Wierenga, Susan Lanooij, Sylvia Keijser, Tara Smit, Don Klinkenberg, Pieter de Boer, Scott McDonald, Amber Maxwell, Annabel Niessen, Danytza Berry, Daphne van Wees, Dimphey van Meijeren, Eric Ra Vos, Frederika Dijkstra, Jeanet Kemmeren, Kylie Ainslie, Marit Middeldorp, Marjolein Kooijman, Timor Faber, Albert Jan van Hoek, Eveline Geubbels, Birgit van Benthem, Jacco Wallinga, Rianne van Gageldonk-Lafeber

Affiliations

¹ Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
² The members of this group (in addition to the named authors) are listed under Investigators.

PMID: 34738514
PMCID: PMC8569927
DOI: 10.2807/1560-7917.ES.2021.26.44.2100977

Abstract

We estimated SARS-CoV-2 vaccine effectiveness against onward transmission by comparing secondary attack rates among household members for vaccinated and unvaccinated index cases, based on source and contact tracing data collected when the Delta variant was dominant. Effectiveness of full vaccination of the index case against transmission to unvaccinated and fully vaccinated household contacts, respectively, was 63% (95% confidence interval (CI): 46-75) and 40% (95% CI: 20-54), in addition to the direct protection of vaccination of contacts against infection.

Keywords: COVID-19; SARS-CoV-2; household study; transmission; vaccine effectiveness.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

COVID-19 Vaccines
COVID-19*
Family Characteristics
Humans
Netherlands / epidemiology
SARS-CoV-2
Vaccines*

Substances

COVID-19 Vaccines
Vaccines