Effectiveness of intra-articular autologous-conditioned serum injection in knee osteoarthritis: a meta-analysis study

Seyed A Raeissadat; Seyed M Rayegani; Mohammad R Sohrabi; Nafisseh Jafarian; Mohammad N Bahrami

doi:10.2144/fsoa-2021-0069

Effectiveness of intra-articular autologous-conditioned serum injection in knee osteoarthritis: a meta-analysis study

Future Sci OA. 2021 Oct 11;7(9):FSO759. doi: 10.2144/fsoa-2021-0069. eCollection 2021 Oct.

Authors

Seyed A Raeissadat¹, Seyed M Rayegani², Mohammad R Sohrabi³, Nafisseh Jafarian⁴, Mohammad N Bahrami⁵

Affiliations

¹ Physiatrist, Associate Professor, Physical Medicine & Rehabilitation Department & Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Physiatrist, Professor, Physical Medicine & Rehabilitation Department & Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Community Medicine Specialist, Professor, Department of Community Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Physiatry Resident, Physical Medicine & Rehabilitation Department & Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁵ Orthopedic Surgeon, Pediatric Orthopedics Fellowship, Orthopedic Surgery Department & Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Aim: Knee osteoarthritis is a common disabling disorder, with no curative treatment. This study aims to assess autologous conditioned serum effectiveness in its treatment.

Materials & methods: Following a systematic search (2000-2020) on major databases and screening and filtering processes, eight articles were included in the final analyses. The pooled effect of visual analog scale (VAS) and the Western Ontario and McMaster Universities (WOMAC) variables was evaluated before and after the intervention.

Results: The combined standardized mean difference for the global WOMAC score was -2.44 and the combined weighted mean difference was -22.92. The combined standardized mean difference for the VAS score was -3.77 and the combined weighted mean difference was -32.37 (p < 0.000).

Conclusion: This meta-analysis reported that the autologous conditioned serum can reduce pain and improve function (VAS and WOMAC outcome measures) in patients with knee osteoarthritis.

Keywords: autologous conditioned serum; intra-articular injection; knee osteoarthritis; meta-analysis; systematic review.

Publication types

Review