Neuroimaging in the term newborn with neonatal encephalopathy

Jessica L Wisnowski; Pia Wintermark; Sonia L Bonifacio; Christopher D Smyser; A James Barkovich; A David Edwards; Linda S de Vries; Terrie E Inder; Vann Chau; Newborn Brain Society Guidelines and Publications Committee

doi:10.1016/j.siny.2021.101304

Neuroimaging in the term newborn with neonatal encephalopathy

Semin Fetal Neonatal Med. 2021 Oct;26(5):101304. doi: 10.1016/j.siny.2021.101304. Epub 2021 Oct 29.

Authors

Jessica L Wisnowski¹, Pia Wintermark², Sonia L Bonifacio³, Christopher D Smyser⁴, A James Barkovich⁵, A David Edwards⁶, Linda S de Vries⁷, Terrie E Inder⁸, Vann Chau⁹; Newborn Brain Society Guidelines and Publications Committee

Affiliations

¹ Departments of Radiology and Pediatrics (Neonatology), Children's Hospital Los Angeles, 4650 Sunset Blvd. MS #81, Los Angeles CA 90027, USA. Electronic address: wisnowsk@usc.edu.
² Department of Pediatrics (Neonatology), McGill University/Montreal Children's Hospital, Division of Newborn Medicine, Research Institute of the McGill University Health Centre, 1001 boul. Décarie, Site Glen Block E, EM0.3244, Montréal, QC H4A 3J1, Canada. Electronic address: pia.wintermark@gmail.com.
³ Division of Neonatal and Developmental Medicine, Department of Pediatrics (Neonatology), Lucile Packard Children's Hospital, Stanford University School of Medicine, 750 Welch Road, Suite 315, Palo Alto, CA 94304, USA. Electronic address: soniab1@stanford.edu.
⁴ Departments of Neurology, Radiology, and Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO 63110-1093, USA. Electronic address: smyserc@wustl.edu.
⁵ Department of Radiology, UCSF Benioff Children's Hospital, University of California San Francisco, 505 Parnassus Avenue, M-391, San Francisco, CA 94143-0628, USA. Electronic address: james.barkovich@ucsf.edu.
⁶ Evelina London Children's Hospital, Centre for Developing Brain, King's College London, Westminster Bridge Road, London, SE1 7EH, United Kingdom. Electronic address: ad.edwards@kcl.ac.uk.
⁷ Department of Neonatology, University Medical Center Utrecht, Utrecht University, Lundlaan 6, 3584 EA, Utrecht, the Netherlands. Electronic address: l.s.devries@umcutrecht.nl.
⁸ Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: tinder@bwh.harvard.edu.
⁹ Department of Pediatrics (Neurology), The Hospital for Sick Children, University of Toronto, 555 University Avenue, Room 6513, Toronto, ON M5G 1X8, Canada. Electronic address: vann.chau@sickkids.ca.

Abstract

Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few published guidelines on neuroimaging for neonates with NE. This review outlines the primary patterns of brain injury associated with hypoxic-ischemic injury in neonates with NE and their frequency, associated neuropathological features, and risk factors. In addition, it provides an overview of neuroimaging methods, including the most widely used scoring systems used to characterize brain injury in these neonates and their utility as predictive biomarkers. Last, recommendations for neuroimaging in neonates with NE are presented.

Keywords: Advanced MRI techniques; Asphyxia; Diffusion-tensor imaging; Diffusion-weighted imaging; Hypoxic-ischemic brain injury; Magnetic resonance spectroscopy imaging; Neonatal encephalopathy; Neonates; Outcome prediction; Predictive values.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain Injuries*
Humans
Hypoxia-Ischemia, Brain* / diagnostic imaging
Infant, Newborn
Infant, Newborn, Diseases* / diagnostic imaging
Magnetic Resonance Imaging
Neuroimaging

Abstract

Publication types

MeSH terms

Grants and funding