Nanomedicine from amphiphilizedprodrugs: Concept and clinical translation

Jiajia Xiang; Xin Liu; Guiping Yuan; Runnan Zhang; Quan Zhou; Tao Xie; Youqing Shen

doi:10.1016/j.addr.2021.114027

Nanomedicine from amphiphilizedprodrugs: Concept and clinical translation

Adv Drug Deliv Rev. 2021 Dec:179:114027. doi: 10.1016/j.addr.2021.114027. Epub 2021 Oct 31.

Authors

Jiajia Xiang¹, Xin Liu², Guiping Yuan³, Runnan Zhang³, Quan Zhou⁴, Tao Xie⁵, Youqing Shen⁶

Affiliations

¹ Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China; Key Laboratory of Biomass Chemical Engineering of the Ministry of Education, College of Chemical and Biological Engineering, Hangzhou, Zhejiang University, Hangzhou 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou, Zhejiang 311215, China.
² Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang 310016, China.
³ Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China; Key Laboratory of Biomass Chemical Engineering of the Ministry of Education, College of Chemical and Biological Engineering, Hangzhou, Zhejiang University, Hangzhou 310027, China.
⁴ School of Basic Medical Sciences, Zhejiang University, Hangzhou 310058, China.
⁵ Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou, Zhejiang 311215, China.
⁶ Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China; Key Laboratory of Biomass Chemical Engineering of the Ministry of Education, College of Chemical and Biological Engineering, Hangzhou, Zhejiang University, Hangzhou 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou, Zhejiang 311215, China. Electronic address: shenyq@zju.edu.cn.

PMID: 34732344
DOI: 10.1016/j.addr.2021.114027

Abstract

Nanomedicines generally consisting of carrier materials with small fractions of active pharmaceutical ingredients (API) have long been used to improve the pharmacokinetics and biodistributions, augment the therapeutic efficacies and mitigate the side effects. Amphiphilizing hydrophobic/hydrophilic drugs to prodrugs capable of self-assembly into well-defined nanostructures has emerged as a facile approach to fabricating nanomedicines because this amphiphilized prodrug (APD) strategy presents many advantages, including minimized use of inert carrier materials, well-characterized prodrug structures, fixed and high drug loading contents, 100% loading efficiency, and burst-free but controlled drug release. This review comprehensively summarizes recent advances in APDs and their nanomedicines, from the rationale and the stimuli-responsive linker chemistry for on-demand drug release to their progress to the clinics, clinical performance of APDs, as well as the challenges and perspective on future development.

Keywords: Amphiphilized prodrug; Clinical translation; Drug delivery; Nanomedicine; Stimuli-responsive.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Delayed-Action Preparations
Drug Development
Drug Evaluation, Preclinical
Drug Liberation
Enzymes / metabolism
Humans
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions*
Nanoparticle Drug Delivery System / chemistry*
Nanoparticle Drug Delivery System / pharmacokinetics*
Oxidation-Reduction
Peptides / chemistry
Polymers / chemistry
Surface-Active Agents / chemistry
Ultraviolet Rays

Substances

Delayed-Action Preparations
Enzymes
Nanoparticle Drug Delivery System
Peptides
Polymers
Surface-Active Agents