Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccines in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Immunogenicity and Reactogenicity

Clin Infect Dis. 2022 Aug 24;75(1):e920-e923. doi: 10.1093/cid/ciab930.

Abstract

The severe acute respiratory syndrome coronavirus 2 messenger RNA vaccine-induced humoral response and reactogenicity profile are described in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Findings showed that 75.0% (by Simoa assay) or 80.0% (by Roche assay) of the HSCT cohort had a positive antibody response on series completion, compared with 100% in the healthy cohort.

Keywords: SARS-CoV-2; immunocompromised; immunogenicity; mRNA vaccines.

MeSH terms

  • COVID-19* / prevention & control
  • Hematopoietic Stem Cell Transplantation* / adverse effects
  • Humans
  • SARS-CoV-2
  • Vaccines
  • Vaccines, Synthetic
  • mRNA Vaccines* / adverse effects

Substances

  • Vaccines
  • Vaccines, Synthetic
  • mRNA Vaccines