Macrocyclic host molecules play the central role in host-guest chemistry and supramolecular chemistry. The highly structural symmetry of macrocyclic host molecules can meet people's pursuit of aesthetics in molecular design, and generally means a balance of design, synthesis, properties and applications. For macrocyclic host molecules with highly symmetrical structures, building blocks, which could be described as repeat units as well, are the most fundamental elements for molecular design. The structural features and recognition ability of macrocyclic host molecules are determined by the building blocks and their connection patterns. Using different building blocks, different macrocyclic host molecules could be designed and synthesized. With decades of developments of host-guest chemistry and supramolecular chemistry, diverse macrocyclic host molecules with different building blocks have been designed and synthesized. Aromatic building blocks are a big family among the various building blocks used in constructing macrocyclic host molecules. In this feature article, the recent developments of macrocyclic host molecules with aromatic building blocks were summarized and discussed.