Intracranial Tumors Associated With IgG4-Related Disease

Dongkyu Kim; Se Hoon Kim; Eui Hyun Kim

doi:10.14791/btrt.2021.9.e17

Intracranial Tumors Associated With IgG4-Related Disease

Brain Tumor Res Treat. 2021 Oct;9(2):93-99. doi: 10.14791/btrt.2021.9.e17.

Authors

Dongkyu Kim¹, Se Hoon Kim², Eui Hyun Kim^{1

3

4}

Affiliations

¹ Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
² Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
³ Pituitary Tumor Center, Severance Hospital, Seoul, Korea.
⁴ Brain Tumor Center, Severance Hospital, Seoul, Korea. euihyunkim@yuhs.ac.

Abstract

IgG4-related disease (IgG4-RD) is an immune-mediated inflammatory condition which is characterized by dense lymphoplasmacytic infiltrations with a predominance of IgG4 plasma cells in the affected tissue. Although pachymeninx and pituitary gland are the most common sites where IgG4-RD infiltrates, the associations with IgG4-RD and a true intracranial tumor have not been yet reported in literature. Herein, we report two cases with intracranial tumors associated with IgG4-RD; a 36-year-old male patient with a huge meningioma and another 54-year old woman with a pituitary macroadenoma. Pathological examination revealed their tumors were substantially infiltrated by IgG4 plasma cells indicating its possible relation with IgG4-RD.

Keywords: IgG4-related disease; Meningioma; Pituitary adenoma.

Publication types

Case Reports