Xingnao Jieyu Decoction Reduces Neuroinflammation through the NF- κ B Pathway to Improve Poststroke Depression

Dou Wang; Tao Li; Xuefei Han; Weiwei He; Yongmei Yan

doi:10.1155/2021/8629714

Xingnao Jieyu Decoction Reduces Neuroinflammation through the NF- κ B Pathway to Improve Poststroke Depression

Evid Based Complement Alternat Med. 2021 Oct 23:2021:8629714. doi: 10.1155/2021/8629714. eCollection 2021.

Authors

Dou Wang^{1

2}, Tao Li^{1

2}, Xuefei Han², Weiwei He², Yongmei Yan^{1

2}

Affiliations

¹ Encephalopathy Hospital, Affiliated Hospital of Shaanxi University of Chinese Medicine, West Weiyang Road, Xianyang, Shaanxi 712000, China.
² First Clinical Medical College, Shaanxi University of Chinese Medicine, West Weiyang Road, Xianyang, Shaanxi 712000, China.

Abstract

The neuroinflammatory pathway regulated by nuclear factor kappa-B (NF-κB) plays an important role in the occurrence, development, and prognosis of poststroke depression (PSD). The regulatory effect of the traditional Chinese medicine compound Xingnao Jieyu decoction (XNJY) on the NF-κB pathway of PSD is still unclear. This study aimed to observe the effect of XNJY on PSD and explore the molecular mechanism of its intervention in the NF-κB pathway. Middle cerebral artery occlusion (MCAO) and chronic unpredictable mild stress were used to establish a PSD rat model. Body mass measurement, behavioral testing, Nissl staining, ELISA, and Western blot were also performed. XNJY and fluoxetine hydrochloride (Flu) treatment of PSD model rats showed significant antidepressant effects. XNJY and Flu treatment could reduce cortical and hippocampal neuronal damage. XNJY reduced inflammation and restored the levels of IL-4, IL-10, and BDNF. In addition, XNJY showed a significant regulatory effect on the NF-κB pathway and the expression of synapse-related proteins PSD-95 and SYN. These results showed that XNJY could significantly reduce the depressive symptoms of PSD rats, and this reduction may be related to the regulation of the NF-κB signaling pathway to improve neuroinflammation and synaptic function.