Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals

Murilo S de Abreu; Konstantin A Demin; Ana C V V Giacomini; Tamara G Amstislavskaya; Tatyana Strekalova; Gleb O Maslov; Yury Kositsin; Elena V Petersen; Allan V Kalueff

doi:10.1016/j.ynstr.2021.100405

Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals

Neurobiol Stress. 2021 Sep 29:15:100405. doi: 10.1016/j.ynstr.2021.100405. eCollection 2021 Nov.

Authors

Murilo S de Abreu^{1

2}, Konstantin A Demin^{3

4

5}, Ana C V V Giacomini^{1

6}, Tamara G Amstislavskaya^{7

8}, Tatyana Strekalova⁹, Gleb O Maslov¹⁰, Yury Kositsin^{4

10}, Elena V Petersen², Allan V Kalueff^{11

12}

Affiliations

¹ Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
² Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
³ Institute of Experimental Medicine, Almazov National Medcial Research Center, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
⁴ Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
⁵ Granov Russian Scientific Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
⁶ Postgraduate Program in Environmental Sciences, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
⁷ Scientific Research Institute of Physiology and Basic Medcicine, Novosibirsk, Russia.
⁸ Novosibirsk State University, Novosibirsk, Russia.
⁹ University of Maastricht, Maasticht, Netherlands.
¹⁰ Neuroscience Program, Sirius University, Sochi, Russia.
¹¹ School of Pharmacy, Southwest University, Chongqing, China.
¹² Ural Federal University, Ekaterinburg, Russia.

Abstract

Stress response is essential for the organism to quickly restore physiological homeostasis disturbed by various environmental insults. In addition to well-established physiological cascades, stress also evokes various brain and behavioral responses. Aquatic animal models, including the zebrafish (Danio rerio), have been extensively used to probe pathobiological mechanisms of stress and stress-related brain disorders. Here, we critically discuss the use of zebrafish models for studying mechanisms of stress and modeling its disorders experimentally, with a particular cross-taxon focus on the potential evolution of stress responses from zebrafish to rodents and humans, as well as its translational implications.

Keywords: Animal models; Behavior; Cortisol; Rodents; Stress axis; Zebrafish.