Extracellular HSP90 Machineries Build Tumor Microenvironment and Boost Cancer Progression

Pietro Poggio; Matteo Sorge; Laura Seclì; Mara Brancaccio

doi:10.3389/fcell.2021.735529

Extracellular HSP90 Machineries Build Tumor Microenvironment and Boost Cancer Progression

Front Cell Dev Biol. 2021 Oct 14:9:735529. doi: 10.3389/fcell.2021.735529. eCollection 2021.

Authors

Pietro Poggio¹, Matteo Sorge¹, Laura Seclì¹, Mara Brancaccio¹

Affiliation

¹ Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.

Abstract

HSP90 is released by cancer cells in the tumor microenvironment where it associates with different co-chaperones generating complexes with specific functions, ranging from folding and activation of extracellular clients to the stimulation of cell surface receptors. Emerging data indicate that these functions are essential for tumor growth and progression. The understanding of the exact composition of extracellular HSP90 complexes and the molecular mechanisms at the basis of their functions in the tumor microenvironment may represent the first step to design innovative diagnostic tools and new effective therapies. Here we review the impact of extracellular HSP90 complexes on cancer cell signaling and behavior.

Keywords: CDC37; CHORDC1; Clusterin; LRP1; Morgana; TLR (toll like receptors); eHSP90 (Extracellular Heat Shock Protein 90); tumor microenvironment.

Publication types

Review