A Critical Review on the Design, Manufacturing and Assessment of the Bone Scaffold for Large Bone Defects

Yi Huo; Yongtao Lu; Lingfei Meng; Jiongyi Wu; Tingxiang Gong; Jia'ao Zou; Sergei Bosiakov; Liangliang Cheng

doi:10.3389/fbioe.2021.753715

A Critical Review on the Design, Manufacturing and Assessment of the Bone Scaffold for Large Bone Defects

Front Bioeng Biotechnol. 2021 Oct 14:9:753715. doi: 10.3389/fbioe.2021.753715. eCollection 2021.

Authors

Yi Huo^{1

2}, Yongtao Lu^{1

2}, Lingfei Meng¹, Jiongyi Wu¹, Tingxiang Gong¹, Jia'ao Zou¹, Sergei Bosiakov³, Liangliang Cheng⁴

Affiliations

¹ Department of Engineering Mechanics, Dalian University of Technology, Dalian, China.
² DUT-BSU Joint Institute, Dalian University of Technology, Dalian, China.
³ Faculty of Mechanics and Mathematics, Belarus State University, Minsk, Belarus.
⁴ Department of Orthopeadics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

Abstract

In recent years, bone tissue engineering has emerged as a promising solution for large bone defects. Additionally, the emergence and development of the smart metamaterial, the advanced optimization algorithm, the advanced manufacturing technique, etc. have largely changed the way how the bone scaffold is designed, manufactured and assessed. Therefore, the aim of the present study was to give an up-to-date review on the design, manufacturing and assessment of the bone scaffold for large bone defects. The following parts are thoroughly reviewed: 1) the design of the microstructure of the bone scaffold, 2) the application of the metamaterial in the design of bone scaffold, 3) the optimization of the microstructure of the bone scaffold, 4) the advanced manufacturing of the bone scaffold, 5) the techniques for assessing the performance of bone scaffolds.

Keywords: additive manufacture; bone scaffold; metamaterial; microstructure design; optimization; performance assessment.

Publication types

Review