Recurrent Fever due to Helicobacter cinaedi Infection during R-CHOP Chemotherapy in Diffuse Large B-Cell Lymphoma: Case Report and Literature Review

Kei Takenaka; Takeshi Sugimoto; Kohei Kawamura; Takeshi Fukumoto; Kenichiro Onuma; Takuya Naito; Masahiro Oka

doi:10.1159/000518685

Recurrent Fever due to Helicobacter cinaedi Infection during R-CHOP Chemotherapy in Diffuse Large B-Cell Lymphoma: Case Report and Literature Review

Case Rep Oncol. 2021 Sep 16;14(3):1315-1322. doi: 10.1159/000518685. eCollection 2021 Sep-Dec.

Authors

Kei Takenaka¹, Takeshi Sugimoto¹, Kohei Kawamura¹, Takeshi Fukumoto², Kenichiro Onuma³, Takuya Naito⁴, Masahiro Oka⁵

Affiliations

¹ Department of Hematology, Kita-Harima Medical Center, Ono City, Japan.
² Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
³ Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan.
⁴ Department of Clinical Laboratory, Kita-Harima Medical Center, Ono City, Japan.
⁵ Department of Dermatology, Kita-Harima Medical Center, Ono City, Japan.

Abstract

Fever due to Helicobacter cinaedi bacteremia under chemotherapy has not been widely recognized among clinicians. We experienced a 72-year-old man with diffuse large B-cell lymphoma, who was complicated with H. cinaedi bacteremia-induced fever under R-CHOP chemotherapy. We summarized 6 cases including ours, suggesting that fever without neutropenia developing around day 6 from starting chemotherapy is a possible symptom caused by H. cinaedi bacteremia. We should discriminate fever due to H. cinaedi bacteremia if fever emerged before myelosuppression in the course of chemotherapy.

Keywords: Chemotherapy; Erythema; Fever; Helicobacter cinaedi.

Publication types

Case Reports