Paraneoplastic Ophthalmoplegia as the Presenting Sign of Paediatric Glioblastoma Multiforme: A Case Report

Arjan S Dhoot; Caroline Just; Lulu Lcd Bursztyn

doi:10.1080/01658107.2020.1817098

Paraneoplastic Ophthalmoplegia as the Presenting Sign of Paediatric Glioblastoma Multiforme: A Case Report

Neuroophthalmology. 2020 Sep 22;45(6):397-402. doi: 10.1080/01658107.2020.1817098. eCollection 2021.

Authors

Arjan S Dhoot¹, Caroline Just², Lulu Lcd Bursztyn^{2

3}

Affiliations

¹ Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
² Department of Clinical Neurological Sciences, Western University Schulich School of Medicine and Dentistry, London, Ontario, Canada.
³ Department of Ophthalmology, Western University Schulich School of Medicine and Dentistry, London, Ontario, Canada.

Abstract

Glioblastoma multiforme (GBM) is an aggressive glioma that is infrequently diagnosed in the paediatric population. GBM and other primary brain tumours have rarely been associated with paraneoplastic syndromes. We report an unusual case of an 8-year-old boy presenting with an inability to abduct his left eye and almost complete ophthalmoplegia of his right eye, prior to any radiological evidence of GBM. This is the first documented case of paediatric GBM presenting with bilateral asymmetric ophthalmoplegia.

Keywords: Ocular motility disorders; central nervous system neoplasms; glioblastoma; ophthalmoplegia; paediatrics; paraneoplastic syndromes.

Publication types

Case Reports