Research progress in gene editing technology

Sheng Huang; Yali Yan; Fei Su; Xiaorui Huang; Dandan Xia; Xinxin Jiang; Yinghui Dong; Ping Lv; Fangyuan Chen; Yanwei Lv

doi:10.52586/4997

Research progress in gene editing technology

Front Biosci (Landmark Ed). 2021 Oct 30;26(10):916-927. doi: 10.52586/4997.

Authors

Sheng Huang^{1

2}, Yali Yan², Fei Su^{1

2}, Xiaorui Huang^{1

2}, Dandan Xia^{1

2}, Xinxin Jiang^{1

2}, Yinghui Dong^{1

2}, Ping Lv^{1

2}, Fangyuan Chen^{1

2}, Yanwei Lv³

Affiliations

¹ Shandong Provincial Key Laboratory of Plant Stress Research, College of Life Science, Shandong Normal University, 250014 Jinan, Shandong, China.
² Bellagen Biotechnology Co., Ltd., 250000 Jinan, Shandong, China.
³ College of Life Sciences, Liaocheng University, 252000 Liaocheng, Shandong, China.

PMID: 34719215
DOI: 10.52586/4997

Abstract

As a tool for modifying the genome, gene editing technology has developed rapidly in recent years, especially in the past two years. With the emergence of new gene editing technologies, such as transposon editing tools, numerous advancements have been made including precise editing of the genome, double base editing, and pilot editing. This report focuses on the development of gene editing tools in recent years, elaborates the progress made in classic editing tools, base editor and other new editing tools, and provides insights into challenges and opportunities.

Keywords: Base editing; Gene editing; New tools; Transposons.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

CRISPR-Cas Systems* / genetics
Gene Editing*
Technology