The Anticonvulsant Lamotrigine Reduces Bout-Like Alcohol Drinking in Rats

Alcohol Alcohol. 2022 Mar 12;57(2):242-245. doi: 10.1093/alcalc/agab073.

Abstract

We used an optical lickometer system to study drinking microstructure and effect of lamotrigine in voluntary alcohol-drinking rats. We showed that, similar to humans, animals differ by their drinking microstructure where some consume alcohol exclusively in a bout-like patterns. The study suggests that anticonvulsants, such as lamotrigine, may be one treatment strategy specifically affecting this type of drinking.

MeSH terms

  • Alcohol Drinking* / drug therapy
  • Animals
  • Anticonvulsants* / pharmacology
  • Anticonvulsants* / therapeutic use
  • Ethanol
  • Lamotrigine
  • Rats

Substances

  • Anticonvulsants
  • Ethanol
  • Lamotrigine