Proton and Multinuclear Spectroscopy of the Pediatric Brain

Matthew T Whitehead; Stefan Bluml

doi:10.1016/j.mric.2021.06.006

Proton and Multinuclear Spectroscopy of the Pediatric Brain

Magn Reson Imaging Clin N Am. 2021 Nov;29(4):543-555. doi: 10.1016/j.mric.2021.06.006.

Authors

Matthew T Whitehead¹, Stefan Bluml²

Affiliations

¹ Department of Radiology, Children's National Hospital, 111 Michigan Avenue NW, Washington, DC 20010, USA; Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA; The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. Electronic address: MWhitehe@childrensnational.org.
² Department of Radiology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, 450 Sunset Boulevard, Los Angeles, CA 90027, USA; Rudi Schulte Research Institute, Santa Barbara, CA, USA.

PMID: 34717844
DOI: 10.1016/j.mric.2021.06.006

Abstract

Magnetic resonance spectroscopy (MRS) is a valuable adjunct to structural brain imaging. State-of-the-art MRS has benefited greatly from recent technical advancements. Neurometabolic alterations in pediatric brain diseases have implications for diagnosis, prognosis, and therapy. Herein, the authors discuss MRS technical considerations and applications in the setting of various pediatric disease processes including tumors, metabolic diseases, hypoxic/ischemic encephalopathy/stroke, epilepsy, demyelinating disease, and infection.

Keywords: (1)H MRS; Metabolic; Metabolism; Multinuclear; Spectroscopy; Tumor.

Publication types

Review

MeSH terms

Brain / diagnostic imaging
Brain Diseases* / diagnostic imaging
Child
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Protons*

Substances

Protons