Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment

Caining Wen; Limei Xu; Xiao Xu; Daping Wang; Yujie Liang; Li Duan

doi:10.1186/s13075-021-02662-0

Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment

Arthritis Res Ther. 2021 Oct 30;23(1):277. doi: 10.1186/s13075-021-02662-0.

Authors

Caining Wen¹, Limei Xu¹, Xiao Xu¹, Daping Wang^{1

2}, Yujie Liang^{3

4}, Li Duan⁵

Affiliations

¹ Department of Orthopedics, Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China.
² Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
³ Department of Orthopedics, Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China. liangyjie@126.com.
⁴ Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, 518003, China. liangyjie@126.com.
⁵ Department of Orthopedics, Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China. duanl@szu.edu.cn.

Abstract

Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. Here, we reviewed the role of IGF-1 in cartilage anabolism and catabolism. Moreover, we discussed the potential role of IGF-1 in OA treatment. Of note, we summarized the recent progress on IGF delivery systems. Optimization of IGF delivery systems will facilitate treatment application in cartilage repair and improve OA treatment efficacy.

Keywords: Cartilage repair; Chondrocytes; IGF-1; Osteoarthritis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cartilage, Articular*
Chondrocytes
Humans
Insulin-Like Growth Factor I
Osteoarthritis*
Signal Transduction

Substances

Insulin-Like Growth Factor I

Abstract

Publication types

MeSH terms

Substances

Grants and funding