Bridging the gap - biomimetic design of bioelectronic interfaces

Aleksander Prominski; Bozhi Tian

doi:10.1016/j.copbio.2021.10.005

Bridging the gap - biomimetic design of bioelectronic interfaces

Curr Opin Biotechnol. 2021 Dec:72:69-75. doi: 10.1016/j.copbio.2021.10.005. Epub 2021 Oct 28.

Authors

Aleksander Prominski¹, Bozhi Tian²

Affiliations

¹ Department of Chemistry, The University of Chicago, Chicago, IL, USA; The James Franck Institute, The University of Chicago, Chicago, IL, USA; The Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA. Electronic address: aprominski@uchicago.edu.
² Department of Chemistry, The University of Chicago, Chicago, IL, USA; The James Franck Institute, The University of Chicago, Chicago, IL, USA; The Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA. Electronic address: btian@uchicago.edu.

PMID: 34717124
DOI: 10.1016/j.copbio.2021.10.005

Abstract

Applied bioelectronic interfaces have an enormous potential for their application in personalized medicine and brain-machine interfaces. While significant progress has been made in the translational applications, there are still concerns about the safety and compliance of artificial devices interacting with cells and tissues. Applying biomimetic design principles enables developing new devices with improved properties in terms of their signal transduction efficiency and biocompatibility. Learning from the paradigms of biological architecture, we can define four cornerstones of biomimetics, which can guide designing new bioelectronic devices or providing improved solutions to challenging biomedical problems. Recent progress shows how these paradigms were successfully employed, for example, to create neuron-like electronics and assemble electronic materials in situ onto the cell membranes using genetic targeting.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biomimetics*