Nuclear Receptors and Transcription Factors in Obesity-Related Kidney Disease

Abstract

Both obesity and chronic kidney disease are increasingly common causes of morbidity and mortality worldwide. Although obesity often co-exists with diabetes and hypertension, it has become clear over the past several decades that obesity is an independent cause of chronic kidney disease, termed obesity-related glomerulopathy. This review defines the attributes of obesity-related glomerulopathy and describes potential pharmacologic interventions. Interventions discussed include peroxisome proliferator-activated receptors, the farnesoid X receptor, the Takeda G-protein-coupled receptor 5, and the vitamin D receptor.

Keywords: Chronic kidney disease (CKD); farnesoid X receptor (FXR); obesity; peroxisome proliferator-activated receptor (PPAR); takeda G-protein–coupled receptor 5 (TGR5); vitamin D receptor (VDR).