Xanthogranulomatous pyelonephritis infected with the Providencia stuartii: a case report and literature review

BMC Nephrol. 2021 Oct 29;22(1):356. doi: 10.1186/s12882-021-02565-x.

Abstract

Background: Xanthogranulomatous pyelonephritis (XGP) is a rare and severe chronic inflammatory disease of the renal parenchyma, which is most commonly associated with super-infections by bacteria such as E. coli, Proteus mirabilis, and occasionally Pseudomonas species.

Case presentation: Herein, we present a rare case of a patient with XGP infected with Providencia stuartii. Initially, the patient refused nephrectomy and underwent holmium laser lithotripsy and right ureteral stenting, followed by meropenem treatment of 7 days. Relapse occurred in the third month after discharge from the hospital, due to which she underwent a radical nephrectomy.

Discussion: The diagnosis of XGP is confirmed by histopathology. The standard treatment for XGP is antibiotic therapy and radical nephrectomy, but partial nephrectomy may be appropriate in select cases.

Keywords: Case report; Diagnosis; Treatment; Xanthogranulomatous pyelonephritis (XGP).

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Enterobacteriaceae Infections*
  • Female
  • Humans
  • Providencia*
  • Pyelonephritis, Xanthogranulomatous / microbiology*

Supplementary concepts

  • Providencia stuartii