Methicillin-resistant Macrococcus canis in a human wound

Infect Genet Evol. 2021 Dec:96:105125. doi: 10.1016/j.meegid.2021.105125. Epub 2021 Oct 26.

Abstract

A hemolytic Macrococcus canis strain (LI021) was isolated for the first time from a human skin infection. The complete genome of LI021 consisting of a 2,216,765-bp circular chromosome was obtained by de novo hybrid assembly of Illumina and Oxford Nanopore technology reads. Strain LI021 belonged to the new sequence type ST75 and was resistant to β-lactam antibiotics due to the presence of a methicillin resistance gene mecB. The mecB gene as well as putative hemolysin genes hlgB and hlgC were located on a novel composite pseudo (Ψ) SCCmec island. These findings show that a methicillin-resistant M. canis may be associated with human infection and indicate that this bacterium should be considered by human diagnostic laboratories.

Keywords: Antibiotic resistance; Dog; Human; Opportunistic pathogen; SCCmec element; WGS.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Genome, Bacterial
  • Gram-Positive Bacterial Infections / microbiology*
  • Humans
  • Methicillin Resistance / genetics*
  • Middle Aged
  • Skin Diseases, Bacterial / microbiology*
  • Staphylococcaceae / classification
  • Staphylococcaceae / drug effects
  • Staphylococcaceae / isolation & purification*
  • Whole Genome Sequencing

Supplementary concepts

  • Macrococcus canis