Illuminating the path to DNA repair

Darshana Gupta; Chase L Beisel

doi:10.1016/j.cell.2021.10.005

Illuminating the path to DNA repair

Cell. 2021 Oct 28;184(22):5503-5505. doi: 10.1016/j.cell.2021.10.005.

Authors

Darshana Gupta¹, Chase L Beisel²

Affiliations

¹ Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Josef-Schneider-Str. 2/D15, 97080 Würzburg, Germany.
² Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Josef-Schneider-Str. 2/D15, 97080 Würzburg, Germany; Medical Faculty, University of Würzburg, Josef-Schneider-Str. 2/D15, 97080 Würzburg, Germany. Electronic address: chase.beisel@helmholtz-hiri.de.

PMID: 34715020
DOI: 10.1016/j.cell.2021.10.005

Abstract

Diverse DNA repair pathways correct ranging types of damage and play central roles in genome editing. In this issue of Cell, two publications leverage a new high-throughput screen that links pathway genes with the outcomes of repair, yielding mechanistic insights into the repair process as well as means to shape editing outcomes.

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MeSH terms

DNA Repair*
Gene Editing*