Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr

Shuai Liu; Cui-Shan Zhang; Xiao-Qian Ran; Xiao-Han Tang; Ya-Rong Guo; Ying Yan; Yong-Gang Yao; Xiao-Jiang Hao; Rong-Can Luo; Ying-Tong Di

doi:10.1039/d1ob01927a

Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr

Org Biomol Chem. 2021 Nov 18;19(44):9637-9640. doi: 10.1039/d1ob01927a.

Authors

Shuai Liu^{1

2}, Cui-Shan Zhang^{1

2}, Xiao-Qian Ran^{3

2}, Xiao-Han Tang¹, Ya-Rong Guo⁴, Ying Yan⁵, Yong-Gang Yao^{3

2

6}, Xiao-Jiang Hao¹, Rong-Can Luo^{2

3}, Ying-Tong Di^{1

2}

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. diyt@mail.kib.ac.cn.
² Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China.
³ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, China. luorongcan@mail.kiz.ac.cn.
⁴ School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
⁵ Guizhou Chemical Drug Research and Development Engineering Technical Center, Guizhou Medicinal University, Guiyang 550004, China.
⁶ CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.

PMID: 34714900
DOI: 10.1039/d1ob01927a

Abstract

Two new quassinoids (1 and 2) were isolated from the twigs of Harrisonia perforata (Blanco) Merr. Perforalactone E (2) possesses an uncommon hexacyclic 1α,12α:5α,13α-dicyclo-9βH-picrasane skeleton. Its structure was determined based on spectroscopic data and X-ray crystallography. Compounds 1 and 2 could significantly induce lysosomal biogenesis through transcriptional activation of lysosomal genes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Simaroubaceae*