Abstract
The bioactivity-guided isolation on the Scutellaria barbata extract resulted in the purification of four undescribed neo-clerodane diterpenoids, scuttenlines A-D (1-4), alone with 20 known diterpenoids (5-24). The chemical structures of them were elaborated by extensive spectroscopic means, including 1D, 2D-NMR and HR-MS. The anti-inflammatory potential ability of 1-24 was screened in lipopolysaccharide-stimulated mouse RAW 264.7 cells. Scuttenline C (IC50 =1.9 μM) and 18 (IC50 =3.7 μM) exhibited potent activity to inhibit NO production.
Keywords:
Labiatae; NO production; Scutellaria barbata; neo-clerodane diterpenoids.
© 2021 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Diterpenes, Clerodane / chemistry
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Diterpenes, Clerodane / isolation & purification
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Diterpenes, Clerodane / pharmacology*
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology
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Mice
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Molecular Conformation
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Nitric Oxide / antagonists & inhibitors
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Nitric Oxide / biosynthesis
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Plant Components, Aerial / chemistry*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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RAW 264.7 Cells
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Scutellaria / chemistry*
Substances
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Anti-Inflammatory Agents
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Diterpenes, Clerodane
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Lipopolysaccharides
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Plant Extracts
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Scutellaria barbata extract
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Nitric Oxide