Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso

Abdou Azaque Zouré; Lanyo Jospin Amegnona; Nayi Zongo; Isabelle Touwendpoulimdé Kiendrebeogo; Pegdwendé Abel Sorgho; Fabienne Ingrid Zongo; Albert Théophane Yonli; Herman Karim Sombié; Aboubacar Hierrhum Bambara; Alexis Yobi Sawadogo; Marie N L Ouedraogo; Lassina Traoré; Sidnooma Véronique Zongo; Doriane Tatiana Lallogo; Bapio Valery Jean Télesphore Elvira Bazié; Théodora M Zohoncon; Florencia W Dijgma; Jacques Simpore

doi:10.1515/biol-2021-0113

Carriage of HLA-DRB111 and 112 alleles and risk factors in patients with breast cancer in Burkina Faso

Open Life Sci. 2021 Oct 11;16(1):1101-1110. doi: 10.1515/biol-2021-0113. eCollection 2021.

Authors

Abdou Azaque Zouré^{1

2

3}, Lanyo Jospin Amegnona¹, Nayi Zongo⁴, Isabelle Touwendpoulimdé Kiendrebeogo^{1

2}, Pegdwendé Abel Sorgho^{1

2}, Fabienne Ingrid Zongo^{1

2}, Albert Théophane Yonli^{1

2}, Herman Karim Sombié^{1

2}, Aboubacar Hierrhum Bambara⁵, Alexis Yobi Sawadogo⁶, Marie N L Ouedraogo^{1

2

7}, Lassina Traoré^{1

2}, Sidnooma Véronique Zongo^{1

2}, Doriane Tatiana Lallogo^{1

2}, Bapio Valery Jean Télesphore Elvira Bazié^{1

2}, Théodora M Zohoncon^{1

2

7}, Florencia W Dijgma^{1

2}, Jacques Simpore^{1

2}

Affiliations

¹ Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, Ouagadougou 03, Burkina Faso.
² Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
³ Department of Biomedical and Public Health/Institute of Health Sciences Research, (IRSS/CNRST), Institute of Health Sciences Research, 03 BP 7192, Ouagadougou 03, Burkina Faso.
⁴ Department of Surgery and Surgical Specialties, Service of General and Digestive Surgery, University Hospital Centre-Yalgado OUEDRAOGO, UFR/SDS, University Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina Faso.
⁵ Department of Medicine and Medical Specialties, Service of Oncology, University Hospital Centre-BOGODOGO, University Joseph KI-ZERBO, UFR/SDS, 03 BP 7021, Ouagadougou 03, Burkina Faso.
⁶ Department of Gynecology-Obstetrics, Service of Gynecology, University Hospital Centre-BOGODOGO, University Joseph KI ZERBO, UFR/SDS, 03 BP 7021, Ouagadougou 03, Burkina Faso.
⁷ Faculty of Medicine, University Saint Thomas d'Aquin, 06 BP 10212, Ouagadougou 01, Burkina Faso.

Abstract

Several factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed breast cancer cases and 102 controls (cases without breast abnormalities). A multiplex polymerase chain reaction (PCR) was used to characterize the carriage of HLA-DRB1*11 and 1*12 alleles. The HLA-DRB1*11 allele was present in 26.59% of cases and 22.55% of controls. The HLA-DRB1*12 allele was present in 56.63% of cases and 55.88% of controls. This study found no direct association between the carriage of the HLA-DRB1*11 and HLA-DRB1*12 alleles and the occurrence of breast cancer. In addition, the deletion of the HLA-DRB1*11 allele is associated (beneficial effect) with obesity/overweight (OR = 0.13; 95% CI [0.01-1.14]; and p = 0.03) which is a risk for breast cancer. No direct association was found between the carriage of HLA-DRB1*11 and 1*12 alleles and breast cancer risk. However, further investigation of other HLA alleles involved in the occurrence of breast cancer may provide more information.

Keywords: Burkina Faso; HLA-DRB1*11; HLA-DRB1*12; breast cancer; risk factors.