Advances in the Relationship Between Pyroptosis and Diabetic Neuropathy

Jingyu Xu; Shufang Cai; Jiaxin Zhao; Ke Xu; Hao Ji; Chengbiao Wu; Jian Xiao; Yanqing Wu

doi:10.3389/fcell.2021.753660

Advances in the Relationship Between Pyroptosis and Diabetic Neuropathy

Front Cell Dev Biol. 2021 Oct 12:9:753660. doi: 10.3389/fcell.2021.753660. eCollection 2021.

Authors

Jingyu Xu¹, Shufang Cai¹, Jiaxin Zhao², Ke Xu¹, Hao Ji¹, Chengbiao Wu³, Jian Xiao², Yanqing Wu¹

Affiliations

¹ Engineering Laboratory of Zhejiang Province for Pharmaceutical Development of Growth Factors, Biomedical Collaborative Innovation Center of Wenzhou, The Institute of Life Sciences, Wenzhou University, Wenzhou, China.
² School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.
³ Clinical Research Center, Affiliated Xiangshan Hospital, Wenzhou Medical University, Wenzhou, China.

Abstract

Pyroptosis is a novel programmed cell death process that promotes the release of interleukin-1β (IL-1β) and interleukin-18 (IL-18) by activating inflammasomes and gasdermin D (GSDMD), leading to cell swelling and rupture. Pyroptosis is involved in the regulation of the occurrence and development of cardiovascular and cerebrovascular diseases, tumors, and nerve injury. Diabetes is a metabolic disorder characterized by long-term hyperglycemia, insulin resistance, and chronic inflammation. The people have paid more and more attention to the relationship between pyroptosis, diabetes, and its complications, especially its important regulatory significance in diabetic neurological diseases, such as diabetic encephalopathy (DE) and diabetic peripheral neuropathy (DPN). This article will give an in-depth overview of the relationship between pyroptosis, diabetes, and its related neuropathy, and discuss the regulatory pathway and significance of pyroptosis in diabetes-associated neuropathy.

Keywords: diabetes; neuroinflammation; neuropathy; oxidative stress; pyroptosis.

Publication types

Review