Early Alterations of Lymphocyte Subsets in Acute Respiratory Distress Syndrome Caused by Acinetobacter baumannii Pneumonia: A Prospective Observational Study

Wei Cheng; Jiahui Zhang; Dongkai Li; Guangxu Bai; Wen Han; Jianwei Chen; Hao Wang; Na Cui

doi:10.3389/fmed.2021.762724

Early Alterations of Lymphocyte Subsets in Acute Respiratory Distress Syndrome Caused by Acinetobacter baumannii Pneumonia: A Prospective Observational Study

Front Med (Lausanne). 2021 Oct 11:8:762724. doi: 10.3389/fmed.2021.762724. eCollection 2021.

Authors

Wei Cheng¹, Jiahui Zhang¹, Dongkai Li¹, Guangxu Bai¹, Wen Han¹, Jianwei Chen¹, Hao Wang², Na Cui¹

Affiliations

¹ State Key Laboratory of Complex Severe and Rare Diseases, Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
² Department of Critical Care Medicine, Beijing Jishuitan Hospital, Beijing, China.

Abstract

Background: To prospectively observe the early alterations of lymphocyte subsets in ARDS caused by Acinetobacter baumannii. Methods: ARDS patients admitted to our ICU between January 1, 2017 and May 30, 2020 were selected. We enrolled all the pulmonary ARDS caused by Acinetobacter baumannii pneumonia who required mechanical ventilation or vasopressors. All the available clinical data, follow up information and lymphocyte subsets were recorded. Results: Eighty-seven of all the 576 ARDS patients were enrolled. The 28-day mortality of the enrolled patients was 20.7% (18/87). The T lymphocyte count (452 vs. 729 cells/ul, P = 0.004), especially the CD8⁺ T lymphocyte count (104 vs. 253 cells/ul, P = 0.002) was significantly lower in non-survivors, as were counts of the activated T cell subsets (CD8⁺CD28⁺ and CD8⁺CD38⁺). The CD8⁺ T cell count was an independent risk factor for 28-day mortality, and a cutoff value of 123 cells/ul was a good indicator to predict the prognosis of ARDS caused by Acinetobacter baumannii pneumonia, with sensitivity of 74.6% and specificity of 83.3% (AUC 0.812, P < 0.0001). Conclusions: Lower CD8⁺ T cell count was associated with higher severity and early mortality in ARDS patients caused by Acinetobacter baumannii pneumonia, which could be valuable for outcome prediction.

Keywords: ARDS; Acinetobacter baumannii; acute respiratory distress syndrome; lymphocyte subset counts; prognosis.