Abstract
A comprehensive study of the functioning of antioxidant system in rats with rotenone-induced parkinsonism was conducted. The development of pathology led to inhibition of the majority of the studied antioxidant enzymes in the brain and blood serum of animals, which can be associated with decompensation of oxidative stress under conditions of prolonged mitochondrial dysfunction. These changes apparently make an important contribution into neuronal degeneration in the cerebral cortex and striatum and motor disorders in experimental animals.
Keywords:
Parkinson’s disease; antioxidant system; oxidative stress; rotenone.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.
MeSH terms
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Animals
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Antioxidants / metabolism
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Brain / drug effects
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Brain / enzymology
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Brain / pathology
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Catalase / genetics
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Catalase / metabolism*
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Gene Expression
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Glutathione / metabolism*
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Glutathione Peroxidase / genetics
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Glutathione Peroxidase / metabolism*
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Glutathione Reductase / genetics
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Glutathione Reductase / metabolism*
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Glutathione Transferase / genetics
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Glutathione Transferase / metabolism*
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Male
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Mitochondria / drug effects
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Mitochondria / enzymology
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Mitochondria / genetics
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Oxidative Stress
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Parkinson Disease, Secondary / chemically induced
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Parkinson Disease, Secondary / enzymology*
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Parkinson Disease, Secondary / genetics
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Parkinson Disease, Secondary / pathology
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Rats
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Rats, Wistar
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Rotenone / toxicity
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Superoxide Dismutase / genetics
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Superoxide Dismutase / metabolism*
Substances
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Antioxidants
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Rotenone
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Catalase
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Glutathione Peroxidase
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Superoxide Dismutase
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Glutathione Reductase
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Glutathione Transferase
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Glutathione