Chickenpox is generally considered a benign childhood disease. However, serious complications may arise. A safe and efficient vaccine is available, and universal chickenpox vaccination is already introduced in many countries. Denmark, among other countries, has been reluctant to introduce the vaccine due to insufficient information on disease burden and concerns regarding herpes zoster incidence and a potential age shift. In this review, we present current knowledge regarding the disease burden of chickenpox in Denmark and discuss perspectives on introducing the vaccine in Denmark.