Prognostic value of malignant T cell-amplified sequence 1 in head and neck squamous cell carcinoma

Biomark Med. 2021 Dec;15(17):1623-1639. doi: 10.2217/bmm-2020-0600. Epub 2021 Oct 27.

Abstract

Aim: To explore the expression profile and prognostic value of MCTS1 in head and neck squamous cell carcinoma (HNSC). Materials & methods: This study used the data from TCGA to HNSC database, GEO database and the data and specimens collected from the patients in our hospital to conduct a comprehensive bioinformatic analysis of MCTS1 in HNSC. Results:MCTS1 was significantly upregulated. MCTS1 mRNA expression level is a potential prognostic biomarker for overall survival and recurrence-free survival. We revealed the potential interactions of MCTS1 with other molecules and potential relationship with ubiquitination, translation initiation and mRNA splicing in HNSC. Conclusion:MCTS1 was significantly upregulated in primary HNSC. The correlation of MCTS1 with poor prognosis suggested its potential as a prognostic marker for HNSC patients.

Keywords: MCTS1; bioinformatic analysis; head and neck cancer; oral squamous cell carcinoma; prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • CpG Islands / genetics
  • DNA Copy Number Variations / genetics
  • DNA Methylation / genetics
  • Female
  • Gene Expression Regulation, Neoplastic
  • Gene Ontology
  • Head and Neck Neoplasms / diagnosis*
  • Head and Neck Neoplasms / metabolism*
  • Head and Neck Neoplasms / pathology
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Molecular Sequence Annotation
  • Mouth Mucosa / metabolism
  • Mouth Mucosa / pathology
  • Multivariate Analysis
  • Neoplasm Staging
  • Oncogene Proteins / genetics
  • Oncogene Proteins / metabolism*
  • Prognosis
  • Protein Interaction Maps / genetics
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • ROC Curve
  • Reproducibility of Results
  • Signal Transduction / genetics
  • Squamous Cell Carcinoma of Head and Neck / diagnosis*
  • Squamous Cell Carcinoma of Head and Neck / metabolism*
  • Squamous Cell Carcinoma of Head and Neck / pathology

Substances

  • Biomarkers, Tumor
  • Cell Cycle Proteins
  • MCTS1 protein, human
  • Oncogene Proteins
  • RNA, Messenger