Abstract
Aim: To explore the expression profile and prognostic value of MCTS1 in head and neck squamous cell carcinoma (HNSC). Materials & methods: This study used the data from TCGA to HNSC database, GEO database and the data and specimens collected from the patients in our hospital to conduct a comprehensive bioinformatic analysis of MCTS1 in HNSC. Results:MCTS1 was significantly upregulated. MCTS1 mRNA expression level is a potential prognostic biomarker for overall survival and recurrence-free survival. We revealed the potential interactions of MCTS1 with other molecules and potential relationship with ubiquitination, translation initiation and mRNA splicing in HNSC. Conclusion:MCTS1 was significantly upregulated in primary HNSC. The correlation of MCTS1 with poor prognosis suggested its potential as a prognostic marker for HNSC patients.
Keywords:
MCTS1; bioinformatic analysis; head and neck cancer; oral squamous cell carcinoma; prognosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism*
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CpG Islands / genetics
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DNA Copy Number Variations / genetics
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DNA Methylation / genetics
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Female
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Gene Expression Regulation, Neoplastic
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Gene Ontology
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Head and Neck Neoplasms / diagnosis*
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Head and Neck Neoplasms / metabolism*
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Head and Neck Neoplasms / pathology
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Humans
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Kaplan-Meier Estimate
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Male
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Middle Aged
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Molecular Sequence Annotation
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Mouth Mucosa / metabolism
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Mouth Mucosa / pathology
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Multivariate Analysis
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Neoplasm Staging
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Oncogene Proteins / genetics
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Oncogene Proteins / metabolism*
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Prognosis
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Protein Interaction Maps / genetics
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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ROC Curve
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Reproducibility of Results
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Signal Transduction / genetics
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Squamous Cell Carcinoma of Head and Neck / diagnosis*
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Squamous Cell Carcinoma of Head and Neck / metabolism*
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Squamous Cell Carcinoma of Head and Neck / pathology
Substances
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Biomarkers, Tumor
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Cell Cycle Proteins
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MCTS1 protein, human
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Oncogene Proteins
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RNA, Messenger