Exclusion of left atrial appendage: effects beyond thromboembolic prevention

Rong Bai; Michael Zawaneh; Peter J Weiss; Wilber W Su

doi:10.1097/HCO.0000000000000936

Exclusion of left atrial appendage: effects beyond thromboembolic prevention

Curr Opin Cardiol. 2022 Jan 1;37(1):10-14. doi: 10.1097/HCO.0000000000000936.

Authors

Rong Bai^{1

2}, Michael Zawaneh^{1

2}, Peter J Weiss^{1

2}, Wilber W Su^{1

2}

Affiliations

¹ Banner University Medical Center.
² University of Arizona School of Medicine, Phoenix Arizona, USA.

PMID: 34698668
DOI: 10.1097/HCO.0000000000000936

Abstract

Purpose of review: This review aims to summarize the nonthromboembolic prevention effects of left atrial appendage exclusion (LAAE).

Recent findings: Left atrial appendage (LAA) secretes multiple hormones; regulates blood volume and pressure; and generates trigger activities. Exclusion of the LAA by different techniques may lead to downstream effects including changes in blood pressure and cardiac performance, improvement of outcome of atrial fibrillation (AF) ablation, and alteration of metabolism.

Summary: LAAE procedures not only prevent thromboembolic events in patients with AF, but rather may bring additional benefits or side-effect to patients undergoing LAAE.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Atrial Appendage* / surgery
Atrial Fibrillation* / complications
Atrial Fibrillation* / surgery
Catheter Ablation* / methods
Humans
Thromboembolism* / etiology
Thromboembolism* / prevention & control
Thromboembolism* / surgery
Treatment Outcome