Biodegradable Polymer with Effective Near-Infrared-II Absorption as a Photothermal Agent for Deep Tumor Therapy

Yingjie Yu; Dongsheng Tang; Chaoyong Liu; Qi Zhang; Lin Tang; Yunfeng Lu; Haihua Xiao

doi:10.1002/adma.202105976

Biodegradable Polymer with Effective Near-Infrared-II Absorption as a Photothermal Agent for Deep Tumor Therapy

Adv Mater. 2022 Jan;34(4):e2105976. doi: 10.1002/adma.202105976. Epub 2021 Nov 28.

Authors

Yingjie Yu¹, Dongsheng Tang^{1

2

3}, Chaoyong Liu¹, Qi Zhang⁴, Lin Tang¹, Yunfeng Lu⁵, Haihua Xiao^{2

3}

Affiliations

¹ State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
² Beijing National Laboratory for Molecular Science, State Key Laboratory of Polymer Physical and Chemistry, Institute of Chemistry, Chinese Academy of Science, Beijing, 100190, China.
³ University of Chinese Academy of Science, Beijing, 100049, China.
⁴ Department of Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
⁵ Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

PMID: 34695252
DOI: 10.1002/adma.202105976

Abstract

Photothermal therapy holds great promise for cancer treatment due to its effective tumor ablation and minimal invasiveness. Herein a new class of biodegradable photothermal agents with effective adsorption in both near-infrared-I (NIR-I) and NIR-II windows is reported for deep tumor therapy. As demonstrated in a deep-seated ovarian cancer model, photothermal therapy using 1064 nm irradiation effectively inhibits tumor progression and prolongs survival spans. This work provides a new design of photothermal agents toward a more effective therapy of tumors.

Keywords: NIR-II window; biodegradability; ovarian cancer model; photothermal agents; photothermal therapy.

MeSH terms

Humans
Neoplasms* / therapy
Phototherapy
Photothermal Therapy
Polymers*
Theranostic Nanomedicine

Substances

Polymers

Abstract

MeSH terms

Substances

Grants and funding