A nationally representative survey (N = 2,213) and five experiments (four preregistered, total N = 1,920) revealed that Whites perceived a foreign cultural threat, or a threat to their American culture and way of life, from the projected growth of racial and ethnic minority populations in their majority-White neighborhoods (Studies 1-5) and schools (Study 6). Whites perceived the increasing presence of Arab Americans, Latinos, and Asian Americans to pose an especially strong degree of perceived foreign cultural threat relative to Black Americans, who were perceived as more threatening than no demographic change. Furthermore, perceptions of foreign cultural threat predicted Whites' desires to move out above and beyond other established intergroup threats (e.g., realistic and symbolic threats). These findings highlight how Whites' concerns about losing their American culture and way of life as racial and ethnic minority groups enter majority-White neighborhoods and schools may contribute to the maintenance of racial segregation. (PsycInfo Database Record (c) 2022 APA, all rights reserved).