Biflavonoids from the twigs and leaves of Cephalotaxus oliveri Mast. and their α-glucosidase inhibitory activity

Min Song; Tong Xiao; Qiu-Shuang Wu; Hang Fai Kwok; Ging Chan; Li-Gen Lin; Xiao-Qi Zhang; Wen-Cai Ye; Sheng-Jiang He; Qing-Wen Zhang

doi:10.1080/14786419.2021.1958328

Biflavonoids from the twigs and leaves of Cephalotaxus oliveri Mast. and their α-glucosidase inhibitory activity

Nat Prod Res. 2022 Jun;36(12):3085-3094. doi: 10.1080/14786419.2021.1958328. Epub 2021 Oct 25.

Authors

Affiliations

¹ State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, P.R. China.
² Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, P.R. China.
³ Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, P.R. China.
⁴ Guangzhou Egg Biotechnology, Co., Ltd, Guangzhou, P.R. China.

PMID: 34694166
DOI: 10.1080/14786419.2021.1958328

Abstract

Three new biflavonoids, umcephabiovins C - E (1 - 3), along with fourteen known compounds were isolated from the twigs and leaves of Cephalotaxus oliveri. Their structures and configurations were elucidated by UV, IR, NMR, ECD, and HR-ESI-MS spectra. Compounds 1 - 3 exhibited significant α-glucosidase inhibitory activity with IC₅₀ values of 7.05 ± 2.66, 24.45 ± 4.73, and 1.84 ± 1.14 μM, respectively. Compound 11 showed moderate cytotoxicity against the BaF3/T315I cell line.

Keywords: Cephalotaxus oliveri; biflavonoids; cytotoxicity; α-glucosidase inhibitory activity.

MeSH terms

Biflavonoids* / chemistry
Biflavonoids* / pharmacology
Cephalotaxus* / chemistry
Molecular Structure
Plant Leaves / chemistry
alpha-Glucosidases / metabolism

Substances

Biflavonoids
alpha-Glucosidases