Copper-Catalyzed Methoxylation of Aryl Bromides with 9-BBN-OMe

Org Lett. 2021 Nov 5;23(21):8450-8454. doi: 10.1021/acs.orglett.1c03172. Epub 2021 Oct 25.

Abstract

A Cu-catalyzed cross-coupling reaction between aryl bromides and 9-BBN-OMe to provide aryl methyl ethers under mild conditions is reported. The oxalamide ligand BHMPO plays a key role in the transformation. Various functional groups on bromobenzenes are well tolerated, providing the desired anisole products in moderate to high yields.