Concurrent IgG4-Related disease and clear cell renal cell carcinoma

Kar Ven Cavan Chow; Shahadat Hossain

doi:10.1016/j.eucr.2021.101856

Concurrent IgG4-Related disease and clear cell renal cell carcinoma

Urol Case Rep. 2021 Sep 16:40:101856. doi: 10.1016/j.eucr.2021.101856. eCollection 2022 Jan.

Authors

Kar Ven Cavan Chow¹, Shahadat Hossain¹

Affiliation

¹ Bundaberg Base Hospital, 271 Bourbong Street Bundaberg Central, Queensland, 4670, Australia.

Abstract

We report a case of a 54-year-old man with a concurrent diagnosis of IgG4-related disease (IgG4-RD) and clear cell renal cell carcinoma (ccRCC) following asymptomatic submandibular lymphadenopathy with an incidental finding of a left renal mass. Partial nephrectomy revealed ccRCC with surrounding lymphoplasmacytic infiltrate, storiform fibrosis and a strong positivity for IgG4 on immunoperoxidase staining. The IgG4+:IgG + ratio was >40% and serum IgG4 levels were elevated at 159mg/dL. This case highlights the concurrent diagnosis of a unique dual pathology within the same organ and emphasises the importance of malignancy screening in patients with IgG4-RD and vice versa.

Keywords: IgG4-related disease; IgG4-related kidney disease; Renal cell carcinoma; Urological malignancy.

Publication types

Case Reports