Prostate-Specific Membrane Antigen Radioguided Surgery for Salvage Pelvic Lymph Node Dissection in a Man With Prostate Cancer

Clin Nucl Med. 2022 Feb 1;47(2):e174-e176. doi: 10.1097/RLU.0000000000003944.

Abstract

A 75-year-old man with evidence of recurrent prostate cancer on 68Ga-prostate-specific membrane antigen (PSMA) PET/CT after radical prostatectomy was referred to our department for 99mTc-PSMA radioguided surgery. Intraoperatively, lymph nodes with high count rates were localized using a handheld gamma probe. High-count specimens were resected from the exact locations as reported by 68Ga-PSMA PET/CT. The total prostate-specific antigen value decreased 6 weeks after surgery. Our case shows the feasibility of radioguided surgery with 99mTc-PSMA for salvage lymphadenectomy in prostate cancer.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Humans
  • Lymph Node Excision
  • Lymphatic Metastasis
  • Male
  • Neoplasm Recurrence, Local
  • Positron Emission Tomography Computed Tomography
  • Prostate
  • Prostatectomy
  • Prostatic Neoplasms* / surgery
  • Radiopharmaceuticals
  • Surgery, Computer-Assisted*

Substances

  • Gallium Isotopes
  • Gallium Radioisotopes
  • Radiopharmaceuticals
  • gallium 68 PSMA-11