Emerging roles for IL-11 in inflammatory diseases

Ka Yee Fung; Cynthia Louis; Riley D Metcalfe; Clara C Kosasih; Ian P Wicks; Michael D W Griffin; Tracy L Putoczki

doi:10.1016/j.cyto.2021.155750

Emerging roles for IL-11 in inflammatory diseases

Cytokine. 2022 Jan:149:155750. doi: 10.1016/j.cyto.2021.155750. Epub 2021 Oct 22.

Authors

Ka Yee Fung¹, Cynthia Louis², Riley D Metcalfe³, Clara C Kosasih³, Ian P Wicks⁴, Michael D W Griffin³, Tracy L Putoczki⁵

Affiliations

¹ Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Victoria 3053, Australia. Electronic address: fung.k@wehi.edu.au.
² Department of Medical Biology, University of Melbourne, Victoria 3053, Australia; Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3052, Australia.
³ Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Technology Institute, University of Melbourne, Victoria 3010, Australia.
⁴ Department of Medical Biology, University of Melbourne, Victoria 3053, Australia; Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3052, Australia; Rheumatology Unit, The Royal Melbourne Hospital, Victoria 3050, Australia.
⁵ Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Victoria 3053, Australia. Electronic address: putoczki.t@wehi.edu.au.

PMID: 34689057
DOI: 10.1016/j.cyto.2021.155750

Abstract

Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also associated with several non-malignant inflammatory diseases where its function remains less well-characterized. Here, we summarize current literature surrounding the contribution of IL-11 to the pathogenesis of autoimmune inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, diabetes and systemic sclerosis, as well as other chronic inflammatory conditions such as periodontitis, asthma, chronic obstructive pulmonary disease, psoriasis and colitis.

Keywords: Autoimmune; GP130; IL-11; Inflammation; STAT3.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autoimmune Diseases / metabolism
Humans
Inflammation / metabolism*
Interleukin-11 / metabolism*

Substances

Interleukin-11