Effects of Ibuprofen Use on Lymphocyte Count and Oxidative Stress in Elite Paralympic Powerlifting

Felipe J Aidar; Guacira S Fraga; Márcio Getirana-Mota; Anderson Carlos Marçal; Jymmys L Santos; Raphael Fabricio de Souza; Alexandre Reis Pires Ferreira; Eduardo Borba Neves; Aristela de Freitas Zanona; Alexandre Bulhões-Correia; Paulo Francisco de Almeida-Neto; Tulio Luiz Banja Fernandes; Nuno Domingos Garrido; Maria do Socorro Cirilo-Sousa; María Merino-Fernández; Alfonso López Díaz-de-Durana; Eugenia Murawska-Ciałowicz; Breno Guilherme de Araújo Tinoco Cabral; Filipe Manuel Clemente

doi:10.3390/biology10100986

Effects of Ibuprofen Use on Lymphocyte Count and Oxidative Stress in Elite Paralympic Powerlifting

Biology (Basel). 2021 Sep 30;10(10):986. doi: 10.3390/biology10100986.

Authors

Felipe J Aidar^{1

2

3

4}, Guacira S Fraga¹, Márcio Getirana-Mota^{1

2}, Anderson Carlos Marçal^{1

2}, Jymmys L Santos^{1

2}, Raphael Fabricio de Souza^{1

2

3}, Alexandre Reis Pires Ferreira⁵, Eduardo Borba Neves⁶, Aristela de Freitas Zanona⁷, Alexandre Bulhões-Correia⁸, Paulo Francisco de Almeida-Neto⁸, Tulio Luiz Banja Fernandes⁹, Nuno Domingos Garrido¹⁰, Maria do Socorro Cirilo-Sousa^{11

12}, María Merino-Fernández¹³, Alfonso López Díaz-de-Durana¹⁴, Eugenia Murawska-Ciałowicz¹⁵, Breno Guilherme de Araújo Tinoco Cabral⁸, Filipe Manuel Clemente^{16

17}

Affiliations

¹ Graduate Program of Physical Education, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil.
² Group of Studies and Research of Performance, Sport, Health and Paralympic Sports (GEPEPS), Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil.
³ Department of Physical Education, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil.
⁴ Graduate Program of Physiological Science, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil.
⁵ College of Physical Education and Exercise Science, University of Brasília (UnB), Brasília 70910-900, Brazil.
⁶ Graduate Program in Biomedical Engineering, Federal Technological University of Paraná (UTFPR), Curitiba 80230-901, Brazil.
⁷ Department of Occupational Therapy, Federal University of Sergipe (UFS), Lagarto 49400-000, Brazil.
⁸ Department of Physical Education, Federal University of Rio Grande do Norte, Natal 59064-741, Brazil.
⁹ Institute of Physical Education and Sport, Federal University of Ceará (UFC), Fortaleza 60020-181, Brazil.
¹⁰ Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal.
¹¹ Graduate Program Association of Physical Education, Federal University of Paraíba (UFPB), João Pessoa 58051-900, Brazil.
¹² Department of Physical Education, Regional of University (URCA), Crato 63105-010, Brazil.
¹³ Faculty of Health Sciences, Universidad Francisco de Vitoria (UFV), 28223 Madrid, Spain.
¹⁴ Sports Department, Physical Activity and Sports Faculty-INEF, Universidad Politécnica de Madrid, 28040 Madrid, Spain.
¹⁵ Physiology and Biochemistry Department, University School of Physical Education, 51-612 Wroclaw, Poland.
¹⁶ Escola Superior Desporto e Lazer, Instituto Politécnico de Viana do Castelo, Rua Escola Industrial e Comercial de Nun'Álvares, 4900-347 Viana do Castelo, Portugal.
¹⁷ Instituto de Telecomunicações, Delegação da Covilhã, 1049-001 Lisboa, Portugal.

Abstract

Background: Paralympic Powerlifting (PP) training tends to promote fatigue and oxidative stress.

Objective: To analyze the effects of ibuprofen use on performance and oxidative stress in post-training PP athletes.

Methodology: Ten national level PP athletes (age: 27.13 ± 5.57) were analyzed for oxidative stress in post-training. The study was carried out in three weeks, (1) familiarization and (2 and 3) evaluated the recovery with the use of a placebo (PLA) and ibuprofen (IBU), 800 mg. The Peak Torque (PT), Torque Development Rate (TDR), Fatigue Index (FI), reactive substances to thiobarbituric acid (TBARS) and sulfhydryl groups (SH) were evaluated. The training consisted of five sets of five repetitions (80-90%) 1-Repetition Maximum (1-RM) in the bench press.

Results: The IBU showed a higher PT (24 and 48 h, p = 0.04, ɳ² p = 0.39), a lower FI (24 h, p = 0.01, ɳ²p = 0.74) and an increased lymphocyte count (p < 0.001; ɳ²p = 4.36). There was no change in oxidative stress.

Conclusions: The use of IBU provided improvements in strength and did not protect against oxidative stress.

Keywords: Paralympic Powerlifting; ibuprofen; muscle strength; oxidative stress; recovery of function.