The Combination of Solid-State Chemistry and Medicinal Chemistry as the Basis for the Synthesis of Theranostics Platforms

Dmitry Korolev; Viktor Postnov; Ilia Aleksandrov; Igor Murin

doi:10.3390/biom11101544

The Combination of Solid-State Chemistry and Medicinal Chemistry as the Basis for the Synthesis of Theranostics Platforms

Biomolecules. 2021 Oct 19;11(10):1544. doi: 10.3390/biom11101544.

Authors

Dmitry Korolev¹, Viktor Postnov^{1

2}, Ilia Aleksandrov¹, Igor Murin²

Affiliations

¹ Almazov National Medical Research Centre, Institute of Experimental Medicine, 2 Akkuratova Str., 197341 Saint Petersburg, Russia.
² Institute of Chemistry, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034 Saint Petersburg, Russia.

Abstract

This review presents the main patterns of synthesis for theranostics platforms. We examine various approaches to the interpretation of theranostics, statistics of publications drawn from the PubMed database, and the solid-state and medicinal chemistry methods used for the formation of nanotheranostic objects. We highlight and analyze chemical methods for the modification of nanoparticles, synthesis of spacers with functional end-groups, and the immobilization of medicinal substances and fluorophores. An overview of the modern solutions applied in various fields of medicine is provided, along with an outline of specific examples and an analysis of modern trends and development areas of theranostics as a part of personalized medicine.

Keywords: early diagnosis; medicinal chemistry; targeted delivery; theranostics; therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chemistry, Pharmaceutical
Drug Delivery Systems
Humans
Nanoparticles / chemistry*
Nanoparticles / therapeutic use
Neoplasms / drug therapy*
Neoplasms / pathology
Precision Medicine / trends*
Theranostic Nanomedicine / trends*