Modelling the Renal Excretion of the Mycotoxin Deoxynivalenol in Humans in an Everyday Situation

Annick D van den Brand; Rudolf Hoogenveen; Marcel J B Mengelers; Marco Zeilmaker; Gunnar S Eriksen; Silvio Uhlig; Anne Lise Brantsæter; Hubert A A M Dirven; Trine Husøy

doi:10.3390/toxins13100675

Modelling the Renal Excretion of the Mycotoxin Deoxynivalenol in Humans in an Everyday Situation

Toxins (Basel). 2021 Sep 22;13(10):675. doi: 10.3390/toxins13100675.

Authors

Annick D van den Brand¹, Rudolf Hoogenveen¹, Marcel J B Mengelers¹, Marco Zeilmaker¹, Gunnar S Eriksen², Silvio Uhlig², Anne Lise Brantsæter³, Hubert A A M Dirven³, Trine Husøy³

Affiliations

¹ National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, The Netherlands.
² Norwegian Veterinary Institute (NVI), P.O. Box 64, 1431 Ås, Norway.
³ Norwegian Institute of Public Health (NIPH), N-0213 Oslo, Norway.

Abstract

The dietary exposure to the mycotoxin deoxynivalenol (DON) can be assessed by human biomonitoring (HBM). Here, we assessed the relation between dietary DON intake and the excretion of its major metabolite DON-15-glucuronide (DON15GlcA) through time, in an everyday situation. For 49 volunteers from the EuroMix biomonitoring study, the intake of DON from each meal was calculated and the excretion of DON and its metabolites was analyzed for each urine void collected separately throughout a 24-h period. The relation between DON and DON15GlcA was analyzed with a statistical model to assess the residence time and the excreted fraction of ingested DON as DON15GlcA (f_{abs_excr}). F_{abs_excr} was treated as a random effect variable to address its heterogeneity in the population. The estimated time in which 97.5% of the ingested DON was excreted as DON15GlcA was 12.1 h, the elimination half-life was 4.0 h. Based on the estimated f_{abs_excr}, the mean reversed dosimetry factor (RDF) of DON15GlcA was 2.28. This RDF can be used to calculate the amount of total DON intake in an everyday situation, based on the excreted amount of DON15GlcA. We show that urine samples collected over 24 h are the optimal design to study DON exposure by HBM.

Keywords: deoxynivalenol; deoxynivalenol-15-glucuronide; dietary exposure; human biomonitoring; human study; mycotoxin; renal excretion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Biological Monitoring
Dietary Exposure / analysis*
Female
Food Contamination / analysis
Glucuronides / metabolism
Glucuronides / urine*
Humans
Male
Middle Aged
Norway
Renal Elimination*
Trichothecenes / metabolism
Trichothecenes / urine*

Substances

Glucuronides
Trichothecenes
deoxynivalenol-15-glucuronide
deoxynivalenol