One dose does not fit all: revising the WHO paediatric dosing tool to include the non-linear effect of body size and maturation

Affiliations

• ¹ Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa. Electronic address: paolo.denti@uct.ac.za.
• ² Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa.
• ³ Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
• ⁴ ICAP, Columbia University, New York, NY, USA.
• ⁵ PHPT/Institut de recherche pour le développement (IRD), MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle) Research Unit, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, UK.
• ⁶ Boston University School of Medicine, Boston, MA, USA.
• ⁷ University of California, San Diego Schools of Medicine and Skaggs School of Pharmacy, La Jolla, CA, USA.
• ⁸ World Health Organization, Geneva, Switzerland.