Saliniquinone Derivatives, Saliniquinones G-I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252

Luning Zhou; Xuedong Chen; Chunxiao Sun; Yimin Chang; Xiaofei Huang; Tianjiao Zhu; Guojian Zhang; Qian Che; Dehai Li

doi:10.3390/md19100575

Saliniquinone Derivatives, Saliniquinones G-I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252

Mar Drugs. 2021 Oct 14;19(10):575. doi: 10.3390/md19100575.

Authors

Luning Zhou¹, Xuedong Chen¹, Chunxiao Sun¹, Yimin Chang¹, Xiaofei Huang¹, Tianjiao Zhu¹, Guojian Zhang^{1

2}, Qian Che¹, Dehai Li^{1

2}

Affiliations

¹ School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
² Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.

Abstract

Four new anthraquinone derivatives, namely saliniquinones G-I (1-3) and heraclemycin E (4), were obtained from the Antarctic marine-derived actinomycete Nocardiopsis aegyptia HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compounds 1 and 2 showed promising inhibitory activity against six tested bacterial strains, including methicillin-resistant coagulase-negative staphylococci (MRCNS), with MIC values ranging from 3.1 to 12.5 μM.

Keywords: GNPS; MRCNS; Nocardiopsis aegyptia; anthraquinone derivatives.

MeSH terms

Animals
Antarctic Regions
Anthraquinones / chemistry
Anthraquinones / pharmacology*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Aquatic Organisms
Microbial Sensitivity Tests
Nocardiopsis
Staphylococcus / drug effects*

Substances

Anthraquinones
Anti-Bacterial Agents

Supplementary concepts

Nocardiopsis aegyptia