COVID-19 reinfection in the presence of neutralizing antibodies

Ju Zhang; Nan Ding; Lili Ren; Rui Song; Danying Chen; Xuesen Zhao; Budong Chen; Junyan Han; Jiarui Li; Yangzi Song; Lin Di; Kai Han; Fengting Yu; Ruming Xie; Zhihai Chen; Wen Xie; Jingyuan Liu; Shan Cen; Yuhai Bi; Angela R Wu; Fujie Zhang; Chen Chen; Hui Zeng

doi:10.1093/nsr/nwab006

COVID-19 reinfection in the presence of neutralizing antibodies

Natl Sci Rev. 2021 Jan 11;8(4):nwab006. doi: 10.1093/nsr/nwab006. eCollection 2021 Apr.

Authors

Ju Zhang¹, Nan Ding¹, Lili Ren², Rui Song¹, Danying Chen¹, Xuesen Zhao¹, Budong Chen¹, Junyan Han¹, Jiarui Li¹, Yangzi Song¹, Lin Di³, Kai Han¹, Fengting Yu¹, Ruming Xie¹, Zhihai Chen¹, Wen Xie¹, Jingyuan Liu¹, Shan Cen⁴, Yuhai Bi⁵, Angela R Wu⁶, Fujie Zhang¹, Chen Chen¹, Hui Zeng¹

Affiliations

¹ Beijing Ditan Hospital, Capital Medical University, China.
² NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
³ Beijing Advanced Innovation Center for Genomics, Biomedical Pioneering Innovation Center, Peking University, China.
⁴ Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, China.
⁵ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, China.
⁶ Division of Life Science and Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, China.

Abstract

After a short recovery period, COVID-19 reinfections could occur in convalescent patients, even those with measurable levels of neutralizing antibodies. Effective vaccinations and protective public health measures are recommended for the convalescent COVID-19 patients.

Keywords: COVID-19; SARS-CoV-2; neutralizing antibody; reinfection.