Synergistic anticancer theragnostic study of a core-shell structured galvanic cell

Bao Jiang; Liping Wang; Gang Wu; Lin Zhou; Shaohua Wei

doi:10.1016/j.colsurfb.2021.112154

Synergistic anticancer theragnostic study of a core-shell structured galvanic cell

Colloids Surf B Biointerfaces. 2022 Jan;209(Pt 2):112154. doi: 10.1016/j.colsurfb.2021.112154. Epub 2021 Oct 15.

Authors

Bao Jiang¹, Liping Wang¹, Gang Wu¹, Lin Zhou², Shaohua Wei³

Affiliations

¹ College of Chemistry and Materials Science, Jiangsu Key Laboratory of Bio-functional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, China.
² College of Chemistry and Materials Science, Jiangsu Key Laboratory of Bio-functional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, China. Electronic address: zhoulin@njnu.edu.cn.
³ College of Chemistry and Materials Science, Jiangsu Key Laboratory of Bio-functional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, China; School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China. Electronic address: shwei@njnu.edu.cn.

PMID: 34673478
DOI: 10.1016/j.colsurfb.2021.112154

Abstract

The chemodynamic therapy (CDT) effect is restricted by the neutral pH environment in the tumor, also, the protein corona formed on the surface of the CDT catalyst reduces its activity. Here, we synthesized a core-shell CDT drug consisting of Fe/Fe₃C core and mesoporous graphite carbon shell with biotin modification (denoted FeCNB). The shell and core form a galvanic cells in the physiological electrolyte solution to achieve high-efficiency CDT under physiological pH conditions. The mesoporous in the shell effectively separates the protein corona from the Fe/Fe₃C, avoiding the influence of the protein corona on the catalyst. However, the mesoporous is permeable for the substrate and product of the catalytic reaction. FeCNB also has T2-magnetic resonance imaging (MRI) function and photothermal conversion ability under 808 nm laser irradiation. The tumor heating further improves the CDT effect to achieve a satisfactory synergistic photothermal therapy (PTT)/CDT outcome. In addition, FeCNB degrades in the microenvironment to ensure its excellent biocompatibility. It is the first study of CDT drug design and fabrication based on the mechanism of the galvanic cells.

Keywords: chemodynamic therapy; galvanic cells; photothermal therapy; protein corona.

MeSH terms

Humans
Hydrogen-Ion Concentration
Neoplasms* / drug therapy
Tumor Microenvironment