A quantitative systems pharmacology approach to support mRNA vaccine development and optimization

CPT Pharmacometrics Syst Pharmacol. 2021 Dec;10(12):1448-1451. doi: 10.1002/psp4.12721. Epub 2021 Oct 21.

Authors

Gianluca Selvaggio¹, Lorena Leonardelli¹, Giuseppe Lofano², Stephanie Fresnay², Silivia Parolo¹, Duccio Medini³, Emilio Siena⁴, Luca Marchetti^{1

5}

Affiliations

¹ Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
² GlaxoSmithKline Vaccines, Rockville, Maryland, USA.
³ Toscana Life Sciences Foundation, Siena, Italy.
⁴ GlaxoSmithKline Vaccines, Siena, Italy.
⁵ Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dendritic Cells / immunology
Drug Development*
Humans
Models, Theoretical*
Network Pharmacology
Neutrophils / immunology
Systems Biology
Vaccines, Synthetic / immunology*
mRNA Vaccines / immunology*

Substances

Vaccines, Synthetic
mRNA Vaccines