Metastatic embryonal rhabdomyosarcoma of the breast: A case report and literature review

Breast J. 2021 Dec;27(12):890-894. doi: 10.1111/tbj.14284. Epub 2021 Oct 21.

Abstract

Rhabdomyosarcoma (RMS) is a common malignancy in children, but embryonal rhabdomyosarcoma (ERMS) deposits rarely occur in the breast in adults. Therefore, little is known about magnetic resonance imaging (MRI) features of breast metastases from RMS, especially the embryonal type. We reported a case of a 22-year-old woman who was diagnosed with ERMS at left foot 2 years ago and accepted operation and chemotherapy. She was confirmed to have breast metastases from the left foot. Successive imaging examinations were performed 3 months apart. Breast ultrasound indicated a benign lesion, and further examination did not reveal any bone metastases. However, predominant restricted diffusion and rim contrast enhancement on MRI combined with the patient's medical history suggested a malignancy of BI-RADS 5. After 3 months, breast ultrasound revealed masses detected last time became larger and lobulated. In addition, internal heterogeneous intensity and rim contrast enhancement with restricted diffusion were revealed on MRI. We speculated that typical MRI findings of breast metastases from RMS may include iso- to hypointensity on T1WI, heterogeneous hyperintensity on T2WI, and circular enhancement with restricted diffusion. Moreover, mild peritumoral edema, rapid expansion of necrosis, and ascending time-intensity curve detected on MRI may be features of the ERMS type.

Keywords: breast metastases; embryonal rhabdomyosarcoma; magnetic resonance imaging.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Breast / pathology
  • Breast Neoplasms* / pathology
  • Child
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods
  • Rhabdomyosarcoma* / pathology
  • Rhabdomyosarcoma, Embryonal* / diagnostic imaging
  • Rhabdomyosarcoma, Embryonal* / pathology
  • Young Adult