Latest Advances in Endothelial Progenitor Cell-Derived Extracellular Vesicles Translation to the Clinic

Amankeldi A Salybekov; Aidyn D Kunikeyev; Shuzo Kobayashi; Takayuki Asahara

doi:10.3389/fcvm.2021.734562

Latest Advances in Endothelial Progenitor Cell-Derived Extracellular Vesicles Translation to the Clinic

Front Cardiovasc Med. 2021 Oct 4:8:734562. doi: 10.3389/fcvm.2021.734562. eCollection 2021.

Authors

Amankeldi A Salybekov^{1

2

3}, Aidyn D Kunikeyev⁴, Shuzo Kobayashi^{2

3}, Takayuki Asahara²

Affiliations

¹ Division of Regenerative Medicine, Department of Center for Clinical and Translational Science, Shonan Kamakura General Hospital, Kamakura, Japan.
² Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura, Japan.
³ Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.
⁴ Department of Software Engineering, Kazakh National Technical University After K.I. Satpayev, Almaty, Kazakhstan.

Abstract

Almost all nucleated cells secrete extracellular vesicles (EVs) that are heterogeneous spheroid patterned or round shape particles ranging from 30 to 200 nm in size. Recent preclinical and clinical studies have shown that endothelial progenitor cell-derived EVs (EPC-EVs) have a beneficial therapeutic effect in various diseases, including cardiovascular diseases and kidney, and lung disorders. Moreover, some animal studies have shown that EPC-EVs selectively accumulate at the injury site with a specific mechanism of binding along with angiogenic and restorative effects that are superior to those of their ancestors. This review article highlights current advances in the biogenesis, delivery route, and long-term storage methods of EPC-EVs and their favorable effects such as anti-inflammatory, angiogenic, and tissue protection in various diseases. Finally, we review the possibility of therapeutic application of EPC-EVs in the clinic.

Keywords: clinical application of EPC exosomes; endothelial progenitor cells; exosomes; extracellular vesicles; miR (microRNA).

Publication types

Review