Nanotechnology Enables Novel Modalities for Neuromodulation

Xiao Yang; Eve McGlynn; Rupam Das; Sergiu P Paşca; Bianxiao Cui; Hadi Heidari

doi:10.1002/adma.202103208

Nanotechnology Enables Novel Modalities for Neuromodulation

Adv Mater. 2021 Dec;33(52):e2103208. doi: 10.1002/adma.202103208. Epub 2021 Oct 19.

Authors

Xiao Yang^{1

2

3

4}, Eve McGlynn⁵, Rupam Das⁵, Sergiu P Paşca^{1

2}, Bianxiao Cui^{3

4}, Hadi Heidari⁵

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
² Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305, USA.
³ Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305, USA.
⁴ Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
⁵ Microelectronics Lab (meLAB), James Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.

Abstract

Neuromodulation is of great importance both as a fundamental neuroscience research tool for analyzing and understanding the brain function, and as a therapeutic avenue for treating brain disorders. Here, an overview of conceptual and technical progress in developing neuromodulation strategies is provided, and it is suggested that recent advances in nanotechnology are enabling novel neuromodulation modalities with less invasiveness, improved biointerfaces, deeper penetration, and higher spatiotemporal precision. The use of nanotechnology and the employment of versatile nanomaterials and nanoscale devices with tailored physical properties have led to considerable research progress. To conclude, an outlook discussing current challenges and future directions for next-generation neuromodulation modalities is presented.

Keywords: nanomaterials; nanotechnology; neural interfaces; neuromodulation.

MeSH terms

Nanotechnology*

Abstract

MeSH terms

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